Effects of withdrawal from an escalating dose schedule of d-amphetamine on sexual behavior in the male rat
by
Barr AM, Fiorino DF, Phillips AG
Department of Psychology,
University of British Columbia,
Vancouver, Canada.
Pharmacol Biochem Behav 1999 Nov; 64(3):597-604

ABSTRACT

The present study sought to determine the effect of withdrawal from an escalating dose schedule of d-amphetamine on sexual behavior in male rats. Tests were conducted every 5 days until stable levels of sexual behavior were obtained. With repeated testing, male rats displayed an increase in their exploration of the testing chambers prior to the introduction of an estrous female. Half of the male rats were then subjected to a 4-day escalating dose schedule of d-amphetamine administration (1-12 mg/kg), while half received vehicle. Twelve hours after the final drug injection, subjects were tested for sexual behavior. Withdrawal from the drug was associated with decrements in several motivational components of sexual behavior, including decreased anticipatory locomotor and increased postejaculatory intervals, while consummatory measures remained largely unaffected. This pattern of sexual deficits resembles those seen in human depressive disorders, and therefore, provides additional support for the use of psychostimulant withdrawal as a rodent model of depression.

Ice
AD/HD
History
Adderall
Dexamyl
Serotonin
The Big Crash
VTA/glutamate
Self-medication
Worms on speed
Dopamine uptake
Canine narcolepsy
The dual deficit model
Methamphetamine FAQ
Amphetamine withdrawal and depression

Refs
and further reading

HOME
HedWeb
Nootropics
cocaine.wiki
Cannabis.net
Future Opioids
BLTC Research
MDMA/Ecstasy
Superhappiness?
Utopian Surgery?
The Good Drug Guide
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World