Phentermine+fenfluramine produce
cocaine-like discriminative cues
by
Schechter MD, McBurney D.
Department of Pharmacology,
Northeastern Ohio Universities,
College of Medicine,
Rootstown 44272, USA.
Life Sci. 1996;59(20):PL303-8

ABSTRACT

Drug discrimination studies were conducted in six male Sprague-Dawley rats trained to discriminate the interoceptive cues produced by 10 mg/kg cocaine in an effort to investigate if there is stimulus generalization to phentermine or phentermine + fenfluramine. Once having reached criterion performance, these rats were tested with lower doses of cocaine and generated a typical dose-response curve allowing for calculation of an ED50 value: 2.798 mg/kg. Testing of phentermine in doses of 1.25-5.0 mg/kg indicated generalization with the highest dose producing 80% cocaine-appropriate responding and allowing for an ED50 value of 2.356 mg/kg. When the phentermine doses were tested in combination 2.0 mg/kg fenfluramine, however, there was an increase in the discriminability of the highest phentermine dose and a slight decrease in the ED50 value of the combination. Thus, administration of phentermine + fenfluramine, having both dopamine-releasing and serotonin-releasing properties, respectively, may mimic the neurochemical activity by which cocaine acts in the central nervous system and may possibly allow for cocaine-like effects as these two drugs see increased use in obesity control.

Phentermine
Sibutramine
Comparisons
CNS stimulants
Slimming drugs
Self-medication
Dopamine uptake
Psychotomimesis
Canine narcolepsy
Appetite suppressants
Fen/phen and the heart
Obsesity: drug treatments
Phentermine and fenfluramine

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